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KMID : 1189420140270040141
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2014 Volume.27 No. 4 p.141 ~ p.157
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Effect of DOGO phreatic water containing germanium on Atopic Dermatitis in NC/Nga mouse
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Lee Jin-Wook
Go Ga-Yeon
Jung Chan-Ho
You Sun-Jong
Kim Yun-Hee
Ahn Taek-Won
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Abstract
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Objectives : The purpose of this study is to investigate the effects of DOGO phreatic water containing germanium on Atopic Dermatitis in NC/Nga mouse.
Methods : We made DOGO phreatic water added germanium. After making atopic dermatitis caused by sensitizing NC/Nga mouse to DNCB(dinitrochlorobenzene), we made mouse swim in tanks each filled with distilled water, tap water, DOGO phreatic water, DOGO phreatic water(added germanium) for 30minutes everyday. 3weeks later, we analyzed skin clinical score, total IgE levels(by ELISA), WBC differential counting(Neutrophils, Monocytes), absolute cell number of $Neutrophil^+Gr-1^+$ 수식 이미지, CCR3 mRNA expressions(by Real-time PCR), IL-4, IFN-${\gamma}$ 수식 이미지 production levels(by ELISA), histologic test(by H&E staining, toluidine blue staining).
Results : The results of making NC/Nga mouse induced atopic dermatitis swim in tanks filled with DOGO phreatic water(contain germanium) are as follows. 1. Skin clinical scores were decreased significantly in comparison to control group. 2. Total IgG levels were decreased significantly in comparison to control group. 3. WBC differential counting(Neutrophils, Monocytes) were decreased significantly in comparison to control group. 4. Absolute cell number of $Neutrophil^+Gr-1^+$ 수식 이미지 were decreased significantly in comparison to control group. 5. CCR3 mRNA expressions were decreased significantly in comparison to control group. 6. IL-4, IFN-${\gamma}$ 수식 이미지 production levels were decreased significantly in comparison to control group. 7. The epithelial tissue thickness, leucocytes infiltration, erythema, edema, excoriation, scaling, mast cells infiltrations in dorsal skin were decreased in comparison to control group.
Conclusions : These results indicate that DOGO phreatic water(contain germanium) can be used for helping treat atopic dermatitis.
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KEYWORD
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DOGO phreatic water, germanium, Atopic Dermatitis, NC/Nga mouse
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